Intramembranous Ossificationĭuring intramembranous ossification, compact and spongy bone develops directly from sheets of mesenchymal (undifferentiated) connective tissue. There are two osteogenic pathways-intramembranous ossification and endochondral ossification-but in the end, mature bone is the same regardless of the pathway that produces it. ![]() By the sixth or seventh week of embryonic life, the actual process of bone development, ossification (osteogenesis), begins. In the early stages of embryonic development, the embryo’s skeleton consists of fibrous membranes and hyaline cartilage.
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